The Non-competitive Inhibition of Brain
نویسنده
چکیده
A non-competitive inhibition by glucose-6-P1 of brain (1, 2) and other animal tissue (1) hexokinases has been described, as well as a similar inhibition of brain hexokinase by L-sorbose-1-P (3). The present paper is concerned with the specificity for inhibition of brain hexokinase by glucose6-P and related compounds. Ry means of a comparison of the structures of twenty-five compounds, six of xvhich are inhibitors, it has been possible to define this specificity. The substrate specificity of brain hexokinase was described in the preceding paper (4).
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